Fig. 3

CDR3 nucleotide and predicted AA sequences retrieved from the TRD cDNA clones. The first column reports the accession numbers of all cDNA sequences. CDR3-IMGT sequences are shown from codon 105 (codon after the 2nd-Cys 104 of the V-REGION) to codon 117 (codon before J-PHE 118 of the J-REGION) according to the IMGT unique numbering [27]. They are grouped on the basis of the absence or the presence of one, two, three and four TRDD genes. Nucleotides of the 3’V-REGION and of the 5’J-REGION are indicated in lower cases. The sequences considered to present recognisable TRDD genes are indicated in bold upper cases with the indication of the TRDD gene name. Nucleotide substitutions with respect to the germline TRDD sequence are indicated in bold lower cases. Nucleotides that cannot be attributed to any V, D or J regions (N-nucleotides) are indicated in capital letters on the left and on the right side, and in between of the TRDD regions. Numbers in the left and right columns indicate the number of nt that are trimmed from the 3’V-REGION and 5’J-REGION, respectively. The last column on the right indicates the TRDJ genes