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Fig 1 | BMC Genomics

Fig 1

From: A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues

Fig 1

RNA-Seq reveals distinct expression patterns for TAp63 and ∆Np63. a Cartoon depicting ∆NP63 (α, β, γ) and TAp63α gene structure. TA β and γ (not shown) undergo similar alternative splicing to ∆NP63 (β, γ). TA, transactivation; Oligo, oligomerization; SAM, sterile alpha motif; TID, transactivation-inhibitory domain; UTR, untranslated region. b Snapshot from UCSC genome browser showing distribution of the aligned RNA-Seq reads at the TP63 locus in representative epithelial cell-lines (Head and neck squamous cell carcinoma (SCC) cell-lines: SCC4 and SCC15) and Non-Hodgkin lymphomas (Burkitt lymphoma cell-lines: Raji and BL2). c Heatmap depicting the expression of p63 isoforms (average across replicates) in FPKM (fragments per kilobase of transcript per million) across representative p63 expressing cell-lines

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