Table 1 Top 5 networks observed to be affected in liver tissue based on differentially expressed transcripts or proteins using Ingenuity Pathway Analysis

Transcriptomics results

Female, Liver, Tissue, 3 mg/k/day

Carbohydrate Metabolism, Behavior, Genetic Disorder

Cellular Growth and Proliferation, Cell Death, DNA Replication, Recombination, and Repair

Cellular Growth and Proliferation, Cellular Movement, Cancer

Cellular Growth and Proliferation, Hematological System Development and Function, Inflammatory Response

Cell-To-Cell Signaling and Interaction, Hair and Skin Development and Function, Tissue Development

Male, Liver Tissue, 3 mg/kg/day

Antigen Presentation, Cell-To-Cell Signaling and Interaction, Hematological System Development and Function

Lipid Metabolism, Molecular Transport, Small Molecular Biochemistry

Cellular Development, Cell Cycle, DNA Replication, Recombination, and Repair

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

Cellular Growth and Proliferation, Small Molecular Biochemistry, Cancer

Female, Liver Tissue, 14 mg,/kg/day

Lipid Metabolism, Small Molecular Biochemistry, Cellular Development

Cell Death, Cellular, Tissue Development

Organismal Injury and Abnormalities, Antigen Presentation, Humoral Immune Response

Cancer, Dermatological Diseases and Conditions, Cellular Development

Cell Death, Organ Morphology, Lipid Metabolism

Male, Liver Tissue, 14 mg/kg/day

Lipid Metabolism, Small Molecular Biochemistry, Cellular Development

Lipid Metabolism, Small Molecular Biochemistry, Cellular Movement

Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism

Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism

Cell-To- Cell Signaling and Interaction, Tissue Development, Cellular Movement

Female, Liver Tissue, 30 mg/kg/day

Organism Functions, Cell Death, Carbohydrate Metabolisms

Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism

Cellular Growth and Proliferation, Skeletal and Muscular System Development and Function, Cellular Function and Maintenance

Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism

Cellular Movement, Nervous System Development and Function, Organ Development

Male, Liver Tissue, 30 mg/kg/day

DNA Replication, Recombination, and Repair, Protein Degradation, Protein Synthesis

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

Lipid Metabolism, Molecular Transport, Small Molecular Biochemistry

Cell Cycle, Cellular Development, Cellular Assembly, and Organization

Cell Cycle, Hair and Skin Development and Function, Cellular Development

Proteomics Results

Female, Liver 30 mg/kg/day

Cell-To-Cell Signaling and Interaction, Tissue Development, Lipid Metabolism

Cell-To-Cell Signaling and Interaction, Tissue Development, Cell Morphology

Amino acid Metabolism, Small Molecular Biochemistry, Cellular Assembly and Organization

Drug Metabolism, Endocrine System Development and Function, Lipid Metabolism

Cell Death, Cellular Growth and Proliferation, Nervous System Development and Function

Male, Liver 30 mg/kg/day

Organismal Injury and Abnormalities, Respiratory Disease, Genetic Disorder

Lipid Metabolism, Molecular Transport, Small Molecular Biochemistry

Cell Morphology, Cellular Development, Nervous System Development and Function

Lipid Metabolism Small, Molecular Biochemistry, Molecular Transport

Gene Expression, Endocrine System Development and Function, Nervous System Development and Function