Fig 5

Distribution of Genes with SD or No RBS over COG Minor Groups. A simple script is used to tally up the frequency of 25 COG minor categories for every RBS motif in every replicon. The minor subgroups fall under the major groups: COG 1. Information storage and processing; COG 2. Cellular processing and signaling; COG 3. Metabolism; and COG 4. Poorly characterized functions. These subgroups include: J. Translation, ribosomal structure and biogenesis (COG 1); A. RNA processing and modification (COG 1); K. Transcription (COG 1); L. Replication, recombination and repair (COG 1); B. Chromatin structure and dynamics (COG 1); D. Cell division and chromosome partitioning (COG 2); Y. Nuclear structure (COG 2); V. Defense mechanisms (COG 2); T. Signal transduction mechanisms (COG 2); M. Cell wall/membrane/envelope biogenesis (COG 2); N. Cell motility (COG 2); Z. Cytoskeleton (COG 2); W. Extracellular structures (COG 2); U. Intracellular trafficking, vesicular transport and secretion (COG 2); O. Posttranslational modification, protein turnover, chaperones (COG 2); C. Energy production and conversion (COG 3); G. Carbohydrate transport and metabolism (COG 3); E. Amino acid transport and metabolism (COG 3); F. Nucleotide transport and metabolism (COG 3); H. Coenzyme metabolism (COG 3); I. Lipid metabolism (COG 3); P. Inorganic ion transport and metabolism (COG 3); Q. Secondary metabolites biosynthesis, transport and catabolism (COG 3); R. General function prediction only (COG 4); and S. Function unknown (COG 4) [31]