Fig. 1

Changepoint detection in base-resolution methylome data. a A scheme for application of changepoint detection to base-resolution methylome data. b Comparison of methylome data for human ESC H1 and fibroblast IMR90 by Lister et al. [4]. A genomic region containing promoters for COMMD7 and DNMT3B genes (chr20, 31,327,500–31,362,500) is shown. Gray dots indicate methylation levels of individual CpG sites that are covered by at least ten reads. Red horizontal bars indicate methylated domains defined by changepoint detection. The vertical level of each bar indicates the mean methylation level of each domain. Blue bars indicate DMRs detected by Lister et al. [4] and by changepoint detection