Fig. 3

MDL plots for methylated domain composition. a MDL plot for mouse ESC [5]. CpG sites covered by at least five reads were used for calculation. Clusters #1 – #3 indicate three major clusters of domains observed in most MDL plots. b Distribution of UMRs, LMRs and FMRs on MDL plot. If more than 80 % of a changepoint detection-defined domain overlaps with previously defined UMRs, LMRs or FMRs [5], the domain was selected and displayed in the plots labelled as UMR, LMR or FMR, respectively. c Comparison of changepoint detection-defined domains with UMRs, LMRs and FMRs in a genomic region around Tbx3 gene (chr5, 120,100,000–120,500,000). d MDL plots for human ESC H1 and fibroblast IMR90 [4]. Yellow dotted lines demarcate the area that fulfils the criteria used to define PMDs in the original study [4]. e MDL plots for human mammary epithelial cells and a low-passage breast cancer cell line [18]