Table 2 Candidate O. unilateralis s.l. neuromodulators
Protein ID | Functional annotation | Fold up during manipulation | Fold down death after manipulation |
|---|---|---|---|
Secondary metabolism | |||
Ophio1_1|g767.t1 | Putative tryptophan dimethyltransferase involved in metabolism of ergot alkaloids, which resemble indole neurotransmitters and are therefore agonists of various neuroreceptors | Infinite | 40.46 |
Ophio1_1|g3491.t1 | Geranylgeranyldiphosphate transferase, PaxC homolog involved in metabolism of indole diterpenes (penitrems) causing tremors through big potassium channel inhibition | 18688.55 | 25.57 |
Ophio1_1|g3493.t1 | Geranylgeranyl pyrophosphate synthase involved in metabolism of terpenoids and polyketides | 14705.25 | 18.60 |
Ophio1_1|g3831.t1 | Putative PKS | 4313.78 | 4.85 |
Ophio1_1|g3492.t1 | Integral membrane protein, PaxB homolog involved in metabolism of indole diterpenes (penitrems) causing tremors through big potassium channel inhibition | 3445.96 | 16.75 |
Ophio1_1|g3487.t1 | Flavin-dependent monooxygenase, PaxM homolog involved in metabolism of indole diterpenes (penitrems) causing tremors through big potassium channel inhibition | 3015.11 | 39.72 |
Ophio1_1|g3485.t1 | Putative tryptophan dimethyltransferase involved in metabolism of ergot alkaloids, which resemble indole neurotransmitters and are therefore agonists of various neuroreceptors | 2293.83 | 28.51 |
Ophio1_1|g768.t1 | NRPS-like protein | 374.06 | 19.74 |
Ophio1_1|g444.t1 | Homolog of P450 involved in fusarin C metabolism cluster | 147.52 | 12.25 |
Ophio1_1|g4784.t1 | Putative NRPS | 6.14 | 8.84 |
Ophio1_1|g3877.t1 | Putative NRPS | 6.03 | 3.77 |
Ophio1_1|g5818.t1 | Putative histidinol-phosphate aminotransferase involved in metabolism of tropane alkaloid scopolamine, which has an antagonist effect on neuroreceptors | 2.91 | 1.17 |
Ophio1_1|g1532.t1 | Acyl-hydrogenase involved in metabolism of terpenoids and polyketides | 2.52 | 2.28 |
Secreted proteins | |||
Ophio1_1|g67605.t1 | SSP, putative lipocalin, ApoD homolog, lipophilic protein binding capacity, involved in brain neuropathologies | Infinite | 17.39 |
Ophio1_1|g209.t1 | SSP, no functional annotation | Infinite | 124.98 |
Ophio1_1|g2647.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | Infinite | 74.44 |
Ophio1_1|g2296.t1 | SignalP, putative bacterial-like enterotoxin involved in pathogenesis and possibly affecting chemosensory compounds | 3263.32 | 199.43 |
Ophio1_1|g4844.t1 | SignalP, putative sphingomyelin phosphodiesterase, ASM, SMPD1 homolog involved in sphingolipid metabolism and therefore cell regulation | 1506.00 | 7.06 |
Ophio1_1|g5103.t1 | SSP, contains ankyrin-repeat, unique to O. unilateralis s.l. | 316.29 | 3.24 |
Ophio1_1|g5079.t1 | SSP, no functional annotation | 118.50 | 3.23 |
Ophio1_1|g3495.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 113.50 | 2.91 |
Ophio1_1|g364.t1 | SignalP, putative protein-tyrosine-phosphatase, involved in ELA behavior induction in Lepidoptera by baculoviruses | 111.28 | 5.39 |
Ophio1_1|g4465.t1 | SSP, putative kynurenine formamidase involved in tryptophan metabolism towards quinolinic acid and kynurenic acid | 102.17 | 6.26 |
Ophio1_1|g734.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 85.48 | 19.28 |
Ophio1_1|g6878.t1 | SSP, no functional annotation | 59.57 | 3.82 |
Ophio1_1|g1605.t1 | SSP, no functional annotation | 51.39 | 11.53 |
Ophio1_1|g3218.t1 | SSP, no functional annotation | 29.14 | 2.92 |
Ophio1_1|g3121.t1 | SSP, no functional annotation | 20.03 | 2.84 |
Ophio1_1|g6661.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 17.31 | 7.61 |
Ophio1_1|g1154.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 17.02 | 2.53 |
Ophio1_1|g2359.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 12.19 | 3.56 |
Ophio1_1|g749.t1 | SignalP, P450, CYP5A ortholog, putative thromboxane-A synthase regulating inflammation levels | 10.39 | 6.36 |
Ophio1_1|g103.t1 | SignalP, tyrosinase involved in dopamine metabolism, melanin production and quinone production | 8.70 | 21.89 |
Ophio1_1|g7417.t1 | SSP, no functional annotation | 8.45 | 2.43 |
Ophio1_1|g3227.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 6.90 | 3.36 |
Ophio1_1|g5581.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 4.64 | 17.27 |
Ophio1_1|g25.t1 | SSP, no functional annotation, unique to O. unilateralis s.l. | 3.72 | 2.97 |
Ophio1_1|g999.t1 | SignalP, tyrosinase involved in dopamine metabolism, melanin production and quinone production | 2.05 | 6.12 |