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Table 2 Candidate O. unilateralis s.l. neuromodulators

From: Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation

Protein ID Functional annotation Fold up during manipulation Fold down death after manipulation
Secondary metabolism
Ophio1_1|g767.t1 Putative tryptophan dimethyltransferase involved in metabolism of ergot alkaloids, which resemble indole neurotransmitters and are therefore agonists of various neuroreceptors Infinite 40.46
Ophio1_1|g3491.t1 Geranylgeranyldiphosphate transferase, PaxC homolog involved in metabolism of indole diterpenes (penitrems) causing tremors through big potassium channel inhibition 18688.55 25.57
Ophio1_1|g3493.t1 Geranylgeranyl pyrophosphate synthase involved in metabolism of terpenoids and polyketides 14705.25 18.60
Ophio1_1|g3831.t1 Putative PKS 4313.78 4.85
Ophio1_1|g3492.t1 Integral membrane protein, PaxB homolog involved in metabolism of indole diterpenes (penitrems) causing tremors through big potassium channel inhibition 3445.96 16.75
Ophio1_1|g3487.t1 Flavin-dependent monooxygenase, PaxM homolog involved in metabolism of indole diterpenes (penitrems) causing tremors through big potassium channel inhibition 3015.11 39.72
Ophio1_1|g3485.t1 Putative tryptophan dimethyltransferase involved in metabolism of ergot alkaloids, which resemble indole neurotransmitters and are therefore agonists of various neuroreceptors 2293.83 28.51
Ophio1_1|g768.t1 NRPS-like protein 374.06 19.74
Ophio1_1|g444.t1 Homolog of P450 involved in fusarin C metabolism cluster 147.52 12.25
Ophio1_1|g4784.t1 Putative NRPS 6.14 8.84
Ophio1_1|g3877.t1 Putative NRPS 6.03 3.77
Ophio1_1|g5818.t1 Putative histidinol-phosphate aminotransferase involved in metabolism of tropane alkaloid scopolamine, which has an antagonist effect on neuroreceptors 2.91 1.17
Ophio1_1|g1532.t1 Acyl-hydrogenase involved in metabolism of terpenoids and polyketides 2.52 2.28
Secreted proteins
Ophio1_1|g67605.t1 SSP, putative lipocalin, ApoD homolog, lipophilic protein binding capacity, involved in brain neuropathologies Infinite 17.39
Ophio1_1|g209.t1 SSP, no functional annotation Infinite 124.98
Ophio1_1|g2647.t1 SSP, no functional annotation, unique to O. unilateralis s.l. Infinite 74.44
Ophio1_1|g2296.t1 SignalP, putative bacterial-like enterotoxin involved in pathogenesis and possibly affecting chemosensory compounds 3263.32 199.43
Ophio1_1|g4844.t1 SignalP, putative sphingomyelin phosphodiesterase, ASM, SMPD1 homolog involved in sphingolipid metabolism and therefore cell regulation 1506.00 7.06
Ophio1_1|g5103.t1 SSP, contains ankyrin-repeat, unique to O. unilateralis s.l. 316.29 3.24
Ophio1_1|g5079.t1 SSP, no functional annotation 118.50 3.23
Ophio1_1|g3495.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 113.50 2.91
Ophio1_1|g364.t1 SignalP, putative protein-tyrosine-phosphatase, involved in ELA behavior induction in Lepidoptera by baculoviruses 111.28 5.39
Ophio1_1|g4465.t1 SSP, putative kynurenine formamidase involved in tryptophan metabolism towards quinolinic acid and kynurenic acid 102.17 6.26
Ophio1_1|g734.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 85.48 19.28
Ophio1_1|g6878.t1 SSP, no functional annotation 59.57 3.82
Ophio1_1|g1605.t1 SSP, no functional annotation 51.39 11.53
Ophio1_1|g3218.t1 SSP, no functional annotation 29.14 2.92
Ophio1_1|g3121.t1 SSP, no functional annotation 20.03 2.84
Ophio1_1|g6661.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 17.31 7.61
Ophio1_1|g1154.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 17.02 2.53
Ophio1_1|g2359.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 12.19 3.56
Ophio1_1|g749.t1 SignalP, P450, CYP5A ortholog, putative thromboxane-A synthase regulating inflammation levels 10.39 6.36
Ophio1_1|g103.t1 SignalP, tyrosinase involved in dopamine metabolism, melanin production and quinone production 8.70 21.89
Ophio1_1|g7417.t1 SSP, no functional annotation 8.45 2.43
Ophio1_1|g3227.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 6.90 3.36
Ophio1_1|g5581.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 4.64 17.27
Ophio1_1|g25.t1 SSP, no functional annotation, unique to O. unilateralis s.l. 3.72 2.97
Ophio1_1|g999.t1 SignalP, tyrosinase involved in dopamine metabolism, melanin production and quinone production 2.05 6.12