Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection

BMC Genomics

Table 1 Baseline characteristics of study subjects by age group

Characteristic	Age Group						All (n = 200)
	3–5 mo (n = 26)	6 mo–1 y (n = 41)	2–5 y (n = 37)	6–11 y (n = 44)	12–17 y (n = 24)	18–25 y (n = 28)
Female gender	11 (42 %)	26 (63 %)	16 (43 %)	23 (52 %)	11 (46 %)	19 (68 %)	106 (53 %)
Bambara ethnicity	21 (81 %)	37 (90 %)	32 (86 %)	38 (86 %)	22 (92 %)	24 (86 %)	174 (87 %)
P. falciparum PCR positive at enrollment^a	0 (0 %)	10 (24 %)	11 (30 %)	4 (9.1 %)	16 (67 %)	14 (50 %)	55 (28 %)
P. malariae PCR positive at enrollment	0	0	0	0	1 (4.2 %)	0	1 (0.5 %)
Stool PCR for intestinal helminths (number positive/number tested)
A. duodenale				0/15	0/24	0/28	0/67
A. lumbricoides				0/11	0/24	0/28	0/63
N. americanus				0/22	0/24	1/28 (3.6 %)	1/74 (1.4 %)
S. stercoralis				0/11	0/24	0/28	0/63
T. trichura				0/11	0/24	0/28	0/63
Kato-Katz for intestinal and urinary helminths (number positive/number tested)
S. mansoni (stool)	0/24	0/40	0/37	0/44	0/24	0/28	0/197
H. nana (stool)	0/24	0/40	0/37	0/44	0/24	0/28	0/197
S.haematobium (urine)	2/19 (11 %)	1/39 (2.6 %)	0/37 (0 %)	1/43 (2.3 %)	2/16 (12 %)	7/22 (32 %)	13/176 (7.4 %)
Hb type
AA	23 (88 %)	35 (85 %)	29 (78 %)	38 (86 %)	22 (92 %)	19 (68 %)	166 (83 %)
AC	1 (3.8 %)	3 (7.3 %)	6 (16 %)	2 (4.5 %)	1 (4.2 %)	3 (11 %)	16 (8 %)
AS	2 (7.7 %)	3 (7.3 %)	2 (5.4 %)	4 (9.1 %)	1 (4.2 %)	5 (18 %)	17 (8.5 %)
SC	0	0	0	0	0	1 (3.6 %)	1 (0.5 %)
Hemoglobin, g/dL (95 % CI)	11.0 (10.7 – 11.3)	10.2 (9.9 – 10.6)	11.1 (10.8 – 11.5)	12.3 (12.0 – 12.6)	13.0 (12.6 – 13.4)	13.5 (12.9 – 14.0)	11.7 (11.5 – 12.0)

^aBefore the malaria season and at time of stool collection. All P. falciparum-infected subjects at the time of enrollment were asymptomatic

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