Fig. 3

Genome-wide distribution of three CTCF binding sequence variations. a The heatmap shows fold-enrichment of 10 histone modifications in the flanking regions ([−1.5kbp, +1.5kbp]) of the three CTCF binding site variations (see Methods) (“▲” indicates the center position of CTCF binding sites). b Distribution of three CTCF binding sequence variations in promoters, enhancers and insulators as annotated by the ENCODE Project. c The distributions of three CTCF binding sequence variations in TSS flanking regions ([−10kbp, +10kbp]). The pie charts show the distributions of the three CTCF binding sequence variations in the whole genome and in promoter regions ([−2500 bp, +500 bp] to TSS); the star (*) indicates a significant difference between the two by the hypergeometric test (p-value < 1E-50; see Additional file 8: Figure S4 for distribution of three CTCF binding sequence variations within other regions)