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Table 1 Suppressors of Q56-YFP toxicity

From: Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

Gene knockout Strain number Gene function Growth of Q56-YFP
arg82Δ 3531 Inositol polyphosphate multikinase (IPMK) --
atp15Δ 1021 Epsilon subunit of mitochondrial ATP synthase --
cem1Δ 198 Mitochondrial beta-keto-acyl synthase --
his7Δ 3388 Imidazole glycerol phosphate synthase ---
hom6Δ 6933 Homoserine dehydrogenase --
ies2Δ 1997 Essential for growth under anaerobic conditions --
kre28Δ 4366 Subunit of a kinetochore-microtubule binding complex --
map1Δ 5153 Methionine aminopeptidase --
ncl1Δ 3050 S-adenosyl-L-methionine-dependent tRNA ---
nfu1Δ 4889 Protein involved in iron metabolism in mitochondria --
rpb9Δ 4437 RNA polymerase II subunit --
rrn10Δ 3051 Subunit of UAF (upstream activation factor) for RNA polymerase I ---
ugo1Δ 4304 Outer membrane component of the mitochondrial fusion machinery --
ybr196c-aΔ 7457 Putative protein of unknown function --
  1. Genes, whose knock-out leads to an enhanced phenotype. The intensity of the phenotype is indicated on a semi-quantitative scale. --- : very strong toxicity, no residual growth, --: residual growth detectable, but stronger toxicity than in the WT background. Gene functions are annotated according to the yeast genome database