Fig. 4
From: C/D box sRNA-guided 2′-O-methylation patterns of archaeal rRNA molecules
Sequence conservation and divergence within orthologous sRNA genes. The notation for box sequences and predicted positions of rRNA modification are described in the legend to Fig. 3. a The Mka sR39 and sR119 sRNAs are derived from duplicate genes and exhibit a high degree of end-to-end sequence similarity. The sR88 has a D box guide that exhibits high similarity to the D' guides of sR39/119 and a D' guide that exhibits only residual similarity to the D guide of sR39/119. The predicted D and D' target sites for sR88 are 23S G3118 and C3169; in our analysis, 16S G152 was not considered a D guide-target for sR88 because it did not meet the prediction criteria. b The Mka sR24 and 25 sequences are derived from duplicated genes. The 5' and 3' regions of the D guides are affected by indels that shift the site of modification between C179 and G176. c The Mka D' guide of sR56 and the D guide of sR103 are highly similar in sequence and are predicted to guide modification to 23S G2759. The D guide of sR56 and the D′ guide of sR103 are unrelated and predicted to guide modification to positions 23S A2849 and G2840 respectively