Fig. 2
From: Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria
Cyanobactin gene cluster from W. intricata UH strain HT-29-1 and precursor analysis. a The cyanobactin gene cluster from W. intricata UH strain HT-29-1 was aligned with the ten gene cluster Nostoc spongiaeforme var. tenue. b Alignments of cyanobactin precursor peptides encoding multiple cyanobactins with precursor peptide sequence from W. intricata UH strain HT-29-1. The highly conserved LAELSEE motif is indicated above the precursor peptide sequences. The core peptide sequences are indicated in the box. Copies of each core peptide sequence range from one to four copies. W. intricata UH strain HT-29-1 encodes two different cyanobactins, with one (TAACAG) and three (TAACAC) copies of each core peptide. LynE from aestuaramide gene cluster (Lyngbya sp. PCC 8106) [94, 95], McaE from microcyclamide gene cluster (Microcystis aeruginosa PCC 7806, PCC 9809 and PCC 9806 respectively) [72, 96], TruE1,2,3 from trunkamide gene cluster (Prochloron) [94], PatE from patellamide gene cluster (Prochloron) [67], VirE from viridisamide gene cluster (Oscillatoria nigro-viridis PCC 7112) [72], AgeE from aeruginosamide gene cluster (Microcystis aeruginosa PCC 9432) [72], TenE from tenuecyclamide gene cluster (Nostoc spongiaeforme var. tenue) [68]; HT291_05652 from putative cyanobactin biosynthetic gene cluster (Westiella intricata UH strain HT-29-1)