Cross-tissue and cross-species analysis of gene expression in skeletal muscle and electric organ of African weakly-electric fish (Teleostei; Mormyridae)

Table 3 Electrical activity

Gene	Protein name	Expression in EO	Pathway/Function	Disrupted phenotype	Reference
atp1a2a	ATPase, Na+/K+ transporting, alpha 2a polypeptide	+	Ion channel transport	Impaired depolarization of the resting membrane potential in slow-twitch fibers of skeletal muscles.	[50]
chrna7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	+	Activation of Nicotinic Acetylcholine Receptors
kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	+	Potassium Channels; GABA receptor activation
kcnq5a	potassium voltage-gated channel, KQT-like subfamily, member 5a	+	Potassium Channels; Synaptic transmission ion currents
grik3	Glutamate Receptor, Ionotropic, Kainate 3	+	Transmission across Chemical Synapses
scn4aa	sodium channel, voltage-gated, type IV, alpha, a	+	Ion channel transport; Axon guidance
kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	-	Potassium Channels; Transmission across Chemical Synapses
kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	-	Potassium Channels; GABA receptor activation
cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	-	Ion channel transport

For each of the shared differentially expressed gene are reported: the gene and protein names obtained from the top hit blast results against the proteome of D. rerio; whether it is up(+)- or down(−)- regulated in the EO; its function or pathway (or both when available); the phenotypic effect on D. rerio of its mis-expression (when available)

ISSN: 1471-2164