Gene | Protein name | Expression in EO | Pathway/Function | Disrupted phenotype | Reference |
---|---|---|---|---|---|
acsbg2 | acyl-CoA synthetase bubblegum family member 2 | - | Fatty acid metabolism | Â | Â |
acsl3b | acyl-CoA synthetase long-chain family member 3b | + | Fatty acid metabolism | Â | Â |
acy1 | Aminoacylase-1 | - | Aminoacids metabolism | Â | Â |
adssl1 | adenylosuccinate synthase like 1 | - | Purine metabolism | Â | Â |
aldoab | Fructose-bisphosphate aldolase | - | Glycolysis | Â | Â |
ampd1 | Adenosine monophosphate deaminase 1 (Isoform M) | - | Purine metabolism | Â | Â |
aoc2 | amine oxidase, copper containing 2 | + | beta-Alanine metabolism | Â | Â |
cds1 | CDP-Diacylglycerol Synthase 1 | + | Glycerophospholipid biosynthesis | Imperfect angiogenesis | [56] |
ckma | creatine kinase, muscle a | - | Metabolism of amino acids and derivatives | Â | Â |
ckmt2a | creatine kinase, mitochondrial 2a (sarcomeric) | - | Metabolism of amino acids and derivatives | Â | Â |
cox4i2 | cytochrome c oxidase subunit IV isoform 2 | - | Oxidative phosphorylation | Â | Â |
cpt2 | carnitine palmitoyltransferase 2 | + | Fatty acid beta-oxidation | Â | Â |
cyp24a1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | - | Steroid biosynthesis | Â | Â |
dhrs9 | dehydrogenase/reductase (SDR family) member 9 | + | Retinol metabolism | Â | Â |
gdpd4a | glycerophosphodiester phosphodiesterase domain containing 4a | + | Glycerol metabolism | Â | Â |
gdpd5a | glycerophosphodiester phosphodiesterase domain containing 5a | + | Glycerol metabolism | Â | Â |
gdpd5b | glycerophosphodiester phosphodiesterase domain containing 5b | + | Glycerol metabolism | Â | Â |
glo1 | Glyoxalase 1 | - | Pyruvate metabolism | Â | Â |
glud1b | glutamate dehydrogenase 1b | - | Nitrogen metabolism | Â | Â |
got2a | glutamic-oxaloacetic transaminase 2a, mitochondrial | - | Glucose metabolism; aminoacids metabolism | Â | Â |
gpib | glucose-6-phosphate isomerase b | - | Gluconeogenesis | Â | Â |
idi1 | isopentenyl-diphosphate delta isomerase 1 | - | Cholesterol biosynthesis | Â | Â |
man1a1 | mannosidase, alpha, class 1A, member 1 | + | N-Glycan biosynthesis | Â | Â |
me3 | malic enzyme 1, NADP(+)-dependent, cytosolic | - | Pyruvate metabolism | Â | Â |
pcyox1 | prenylcysteine oxidase 1 | - | Terpenoid backbone biosynthesis | Â | Â |
pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | - | Glycolysis | Â | Â |
pgam2 | phosphoglycerate mutase 2 (muscle) | - | Glycolysis and Gluconeogenesis | Â | Â |
pgm5 | Phosphoglucomutase 5 | - | Glucuronidation | Failure in myofibril assembly | [57] |
ucp3 | uncoupling protein 3 | - | Respiratory electron transport | Â | Â |
ugp2b | UDP-glucose pyrophosphorylase 2b | - | Glucose metabolism | Â | Â |
gyg1a | glycogenin 1a | - | Glycogen Metabolism | Â | Â |
mid1ip1l | MID1 interacting protein 1, like | - | lipid metabolic process | Â | Â |