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Table 5 Metabolism

From: Cross-tissue and cross-species analysis of gene expression in skeletal muscle and electric organ of African weakly-electric fish (Teleostei; Mormyridae)

Gene

Protein name

Expression in EO

Pathway/Function

Disrupted phenotype

Reference

acsbg2

acyl-CoA synthetase bubblegum family member 2

-

Fatty acid metabolism

  

acsl3b

acyl-CoA synthetase long-chain family member 3b

+

Fatty acid metabolism

  

acy1

Aminoacylase-1

-

Aminoacids metabolism

  

adssl1

adenylosuccinate synthase like 1

-

Purine metabolism

  

aldoab

Fructose-bisphosphate aldolase

-

Glycolysis

  

ampd1

Adenosine monophosphate deaminase 1 (Isoform M)

-

Purine metabolism

  

aoc2

amine oxidase, copper containing 2

+

beta-Alanine metabolism

  

cds1

CDP-Diacylglycerol Synthase 1

+

Glycerophospholipid biosynthesis

Imperfect angiogenesis

[56]

ckma

creatine kinase, muscle a

-

Metabolism of amino acids and derivatives

  

ckmt2a

creatine kinase, mitochondrial 2a (sarcomeric)

-

Metabolism of amino acids and derivatives

  

cox4i2

cytochrome c oxidase subunit IV isoform 2

-

Oxidative phosphorylation

  

cpt2

carnitine palmitoyltransferase 2

+

Fatty acid beta-oxidation

  

cyp24a1

cytochrome P450, family 24, subfamily A, polypeptide 1

-

Steroid biosynthesis

  

dhrs9

dehydrogenase/reductase (SDR family) member 9

+

Retinol metabolism

  

gdpd4a

glycerophosphodiester phosphodiesterase domain containing 4a

+

Glycerol metabolism

  

gdpd5a

glycerophosphodiester phosphodiesterase domain containing 5a

+

Glycerol metabolism

  

gdpd5b

glycerophosphodiester phosphodiesterase domain containing 5b

+

Glycerol metabolism

  

glo1

Glyoxalase 1

-

Pyruvate metabolism

  

glud1b

glutamate dehydrogenase 1b

-

Nitrogen metabolism

  

got2a

glutamic-oxaloacetic transaminase 2a, mitochondrial

-

Glucose metabolism; aminoacids metabolism

  

gpib

glucose-6-phosphate isomerase b

-

Gluconeogenesis

  

idi1

isopentenyl-diphosphate delta isomerase 1

-

Cholesterol biosynthesis

  

man1a1

mannosidase, alpha, class 1A, member 1

+

N-Glycan biosynthesis

  

me3

malic enzyme 1, NADP(+)-dependent, cytosolic

-

Pyruvate metabolism

  

pcyox1

prenylcysteine oxidase 1

-

Terpenoid backbone biosynthesis

  

pfkfb1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

-

Glycolysis

  

pgam2

phosphoglycerate mutase 2 (muscle)

-

Glycolysis and Gluconeogenesis

  

pgm5

Phosphoglucomutase 5

-

Glucuronidation

Failure in myofibril assembly

[57]

ucp3

uncoupling protein 3

-

Respiratory electron transport

  

ugp2b

UDP-glucose pyrophosphorylase 2b

-

Glucose metabolism

  

gyg1a

glycogenin 1a

-

Glycogen Metabolism

  

mid1ip1l

MID1 interacting protein 1, like

-

lipid metabolic process

  
  1. For each of the shared differentially expressed gene are reported: the gene and protein names obtained from the top hit blast results against the proteome of D. rerio; whether it is up(+)- or down(−)- regulated in the EO; its function or pathway (or both when available); the phenotypic effect on D. rerio of its mis-expression (when available)