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Table 6 Transcription factors

From: Cross-tissue and cross-species analysis of gene expression in skeletal muscle and electric organ of African weakly-electric fish (Teleostei; Mormyridae)

Gene

Protein name

Expression in EO

Pathway/Function

Disrupted phenotype

Reference

eng1b

engrailed homeobox 1b

+

neuron fate commitment

  

her6

hairy-related 6

+

Notch signaling pathway

  

hes6

hes family bHLH transcription factor 6

+

Notch signaling pathway

  

hey1

hes-related family bHLH transcription factor with YRPW motif 1

+

Notch signaling pathway

  

hipk2

homeodomain interacting protein kinase 2

+

Wnt signaling pathway; p53 Signaling; ERK Signaling

Induced apoptosis

[58]

hoxc11a

homeobox C11a

+

   

hoxd11a

homeobox D11a

+

   

mef2aa

myocyte enhancer factor 2aa

+

Signaling by FGFR

Abnormal development of posterior somites

[29]

mef2b

myocyte enhancer factor 2b

+

miRs in Muscle Cell Differentiation

  

rb1

retinoblastoma 1

+

E2F mediated regulation of DNA replication; Cell cycle

Abnormal retina development

[59]

taf6

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor

+

GPCR Pathway

  

arxa

aristaless related homeobox a

-

Axon guidance

Abnormal dopaminergic neurons development

[60]

klf15

Kruppel-like factor 15

-

Adipogenesis

  

pbxip1

pre-B-cell leukemia homeobox interacting protein 1

-

   

myf6

myogenic factor 6

-

Myogenesis

Disrupted myogenesis

[28]

myog

myogenin

-

Myogenesis

Disrupted myogenesis

[27]

nfatc1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

-

Wnt signaling pathway

  

nr0b2a

nuclear receptor subfamily 0, group B, member 2a

-

Nuclear Receptor transcription pathway; NOD-like Receptor Signaling Pathways

  

pitx2

paired-like homeodomain 2

-

retinoic acid receptor signaling pathway

Abnormal eye and craniofacial development

[61]

rxrgb

retinoid X receptor, gamma b

-

steroid hormone receptor activity; retinoic acid receptor signaling pathway

  

six1b

SIX homeobox 1b

-

regulation of skeletal muscle cell proliferation

Abnormal trunk musculature development

[62]

six4b

SIX homeobox 4b

-

regulation of skeletal muscle cell proliferation

  

tbx15

T-box 15

-

regulation of transcription, DNA-templated

  
  1. For each of the shared differentially expressed gene are reported: the gene and protein names obtained from the top hit blast results against the proteome of D. rerio; whether it is up(+)- or down(−)- regulated in the EO; its function or pathway (or both when available); the phenotypic effect on D. rerio of its mis-expression (when available)
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BMC Genomics

ISSN: 1471-2164

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