Fig. 5

Body weight loss of Irf7 and Reg3g knock-out mice after influenza A infection. Female mice were infected with 2x10⁵ FFU PR8M by intranasal application. Mice with a weight loss of more than 30 % of the starting weight had to be euthanized and were recorded as dead. a Homozygous Irf7 ^−/− mice showed higher body weight loss (on days 6 to day 8 p.i., p < 0.05, Mann Whitney U test) and (b) significantly increased mortality (Log-rank test, p < 0.01) compared to C57BL/6J control mice. c Mutant Reg3g ^−/− mice exhibited significant differences in body weight loss at days 4, 5, 6, 9, and 10 p.i. (Mann Whitney U test, p < 0.05) but no significant increase in mortality (Log-rank test). Please note that in (a) after day 6 p.i. only the surviving mice are shown and are thus not representative for the entire group