Transcriptomic changes of Legionella pneumophila in water

Li, Laam; Mendis, Nilmini; Trigui, Hana; Faucher, Sébastien P.

doi:10.1186/s12864-015-1869-6

BMC Genomics

Table 1 Selected genes significantly down-regulated in water

From: Transcriptomic changes of Legionella pneumophila in water

			Log₂ ratio^a
Functional class and protein	Locus tag	Gene	2 hr/C	6 hr/C	24 hr/C
Cell division
Cell division protein	lpg2610	ftsA		−1.12	−2.93
Cell division protein	lpg2611	ftsQ	−1.18	−1.28	−4.43
Cell division protein	lpg2615	ftsW		−2.34	−5.59
Energy metabolism
ATP synthase F₀, A subunit	lpg2988	atpB	−1.38	−2.58	−3.49
ATP synthase F₀, C subunit	lpg2987	atpE		−1.27	−2.58
ATP synthase F₀, I subunit	lpg2989	atpI		−1.13	−2.51
ATP synthase F₁, alpha subunit	lpg2984			−1.77	−1.71
ATP synthase F₁, beta subunit	lpg2982	atpD	−1.19	−2.53	−2.44
ATP synthase F₁, epsilon subunit	lpg2981	atpC		−1.67	−4.33
ATP synthase F₁, gamma subunit	lpg2983	atpG	−1.36	−2.16	−2.60
ATP synthase F₁,delta subunit	lpg2985	atpH		−1.89	−2.15
Cytochrome c oxidase, subunit I	lpg2896			−1.71	−3.10
Cytochrome c oxidase, subunit II	lpg2897			−2.38	−3.10
Cytochrome c	lpg2898			−1.16	−1.64
NADH dehydrogenase I, A subunit	lpg2789	nuoA	−1.56	−3.42	−6.44
NADH dehydrogenase I, B subunit	lpg2788	nuoB2	−4.60	−6.26	−8.44
NADH dehydrogenase I, C subunit	lpg2787	nuoC	−1.16	−3.34	−4.65
NADH dehydrogenase I, H subunit	lpg2782	nuoH	−1.72	−3.71	−6.66
NADH dehydrogenase I, I subunit	lpg2781	nuoI	−1.00	−2.82	−4.16
Succinate dehydrogenase	lpg0528	sdhC			−2.94
Succinate dehydrogenase	lpg0530	sdhA			−2.48
Succinate dehydrogenase	lpg0531	sdhB	−1.01		−2.93
Ubiquinol-cytochrome c reductase	lpg2704	petB		−1.66	−5.08
Ubiquinol-cytochrome c reductase	lpg2705	petA		−1.46	−2.54
Signal transduction/other regulatory functions
Response regulator	lpg1912	letS		−1.15
Response regulator	lpg2646	letA	−4.02	−3.57	−5.46
Toxin production/other pathogen functions
Macrophage infectivity potentiator	lpg0791	mip	−1.22		−2.04
Transcription
DNA-directed RNA polymerase alpha subunit	lpg0354	rpoA	−2.70	−3.95
DNA-directed RNA polymerase beta subunit	lpg0322	rpoB	−1.74	−2.63
DNA-directed RNA polymerase beta' subunit	lpg0323	rpoC			−2.83
RNA polymerase sigma-32 factor	lpg2667	rpoH			−2.09
Translation
30S ribosomal protein S13	lpg0351	rpsM	−2.57	−4.22	−5.00
30S ribosomal protein S20	lpg2636	rpsT	−3.86	−4.43	−6.92
30S ribosomal protein S6	lpg1592	rpsF	−2.99	−4.18	−4.84
30S ribosomal protein S7	lpg0325	rpS7	−2.43	−3.36	−3.89
50S ribosomal protein L15	lpg0348	rplO	−1.76	−3.37	−3.21
50S ribosomal protein L16	lpg0336	rplP	−2.49	−3.73	−3.21
50S ribosomal protein L28	lpg0479	rpmB	−2.00	−2.89	−3.40
50S ribosomal protein L6	lpg0344	rplF	−2.49	−3.81	−3.47
Translation elongation factor G	lpg0326	fusA	−2.45	−2.59
Translation elongation factor Ts	lpg1713	tsf		−1.40	−1.20
Translation initiation factor IF-1	lpg1770	infA	−2.47	−3.69	−5.00
Translation initiation factor IF-3	lpg2713	infC	−3.20	−3.29
tRNA-Gly	lpg2292		−3.05	−3.10	−3.76
tRNA-Met	lpg0797		−2.99	−3.68	−5.53
tRNA-Phe	lpg1929		−3.29	−3.63	−4.44
tRNA-Pro	lpg1866		−3.54	−4.49	−5.83
Transport and binding
Amino acid antiporter	lpg1658		−2.19	−3.66	−5.86
Amino acid antiporter	lpg1691		−2.89	−3.61	−4.31
Amino acid antiporter	lpg1917		−2.51	−4.11	−4.80
Amino acid permeases	lpg0970		−1.91	−3.42	−5.45
Amino acid permease family protein	lpg0228		−2.77	−5.41	−6.13
Amino acid transporter	lpg0049				−3.27
Ferrous iron transporter	lpg2658	feoA	−2.56	−2.80	−4.47
Ferrous iron transporter	lpg2657	feoB		−3.10	−5.23
DotA	lpg2686	dotA			−1.35
DotC	lpg2675	dotC	−1.40	−2.29	−4.72
DotD	lpg2674	dotD		−1.46	−3.67
DotK	lpg0447	lphA	−2.59	−1.69	−5.16
IcmB (DotO)	lpg0456	icmB			−3.00
IcmC (DotE)	lpg0453	icmC		1.27	−1.11
IcmF	lpg0458	icmF			−1.13
IcmH (DotU)	lpg0459	icmH	−2.95	−2.42	−5.33
IcmJ (DotN)	lpg0455	icmJ			−1.69
IcmK (DotH)	lpg0450	icmK		−2.10	−4.11
IcmL (DotI)	lpg0449	icmL		−1.93	−5.42
IcmL homolog	lpg0708				−2.65
IcmL homolog	lpg0383				−2.81
IcmM (DotJ)	lpg0448	icmM			−2.57
IcmO (DotL)	lpg0446	icmO		2.07	−1.50
IcmQ	lpg0444	icmQ			−1.36
IcmR	lpg0443	icmR			−2.16
IcmS	lpg0442	icmS			−2.43
IcmT	lpg0441	icmT	1.39	1.79	−1.09
IcmV	lpg2687	icmV	1.00		−1.89
IcmW	lpg2688	icmW			−3.09
IcmX (IcmY)	lpg2689	icmX			−1.41
Type IV pilus biogenesis protein	lpg0927	pilM			−2.04
Type IV pilus biogenesis protein	lpg0928	pilN	−1.36		−2.74
Type IV pilus biogenesis protein	lpg0930	pilP			−3.66

^aOnly values that were significantly different than the control are shown

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