Table 3 Genes whose deletion causes enhanced resistance to caspofungin
ORF | Gene | Functional group | Description | ||
|---|---|---|---|---|---|
YBR105C | VID24 | • | CR | carbohydrate metabolism | GID Complex regulatory subunit involved in response to glucose through interactions with complex member Vid28 |
YCL061C | MCR1 | cell cycle | S-phase checkpoint protein required for DNA replication | ||
YJL157C | FAR1 | cell cycle | Inhibitor of Cdc28-Cln1 and Cdc28-Cln2 kinase complexes involved in cell cycle arrest for matin | ||
YOR008C | SLG1 | • | cell wall | Sensor-transducer of the stress-activated CWI kinase pathway involved in maintenance of cell wall integrity | |
YBR026C | ETR1 | lipid metabolism | 2-enoyl thioester reductase with a probable role in fatty acid synthesis | ||
YBR036C | CSG2 | • | CR | lipid metabolism | ER membrane protein required for mannosylation of inositol phosphorylceramide (sphingolipids biosynthesis) |
YCR034W | ELO2 | • | CR | lipid metabolism | Fatty acid elongase involved in sphingolipid biosynthesis |
YGR263C | SAY1 | lipid metabolism | Sterol deacetylase, component of the sterol acetylation/deacetylation cycle along with Atf2 | ||
YLR056W | ERG3 | • | lipid metabolism | C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol (ergosterol biosynthesis) | |
YLR372W | ELO3 | • | CR | lipid metabolism | Elongase involved in fatty acid and sphingolipid biosynthesis |
YNL156C | NSG2 | lipid metabolism | Protein involved in regulation of sterol biosynthesis stabilizing Hmg2 protein | ||
YPL057C | SUR1 | • | CR | lipid metabolism | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit (sphingolipids biosynthesis) |
YPL118W | MRP51 | CR | mitochondrial | Mitochondrial ribosomal protein of the small subunit | |
YBR048W | RPS11B | protein metabolism | Protein component of the small (40S) ribosomal subunit | ||
YBL075C | SSA3 | stress | ATPase, member of the heat shock protein 70 (HSP70) family, involved in protein folding and the response to stress | ||
YNL080C | EOS1 | • | stress | Protein involved in N-glycosylation | |
YOR061W | CKA2 | • | CR | transcription | Alpha' catalytic subunit of casein kinase 2 (CK2) a Ser/Thr protein kinase with roles in cell growth and proliferation |
YNL323W | LEM3 | • | transport | Protein of the plasma membrane and ER involved in translocation of phospholipids across the plasma membrane | |
YBL029W | unknown | Non-essential protein of unknown function | |||
YBR071W | unknown | Protein of unknown function, may be regulated by the cell cycle and/or cell wall stress | |||
YDR360W | OPI7 | unknown | Dubious open reading frame, partially overlaps verified gene VID21/YDR359C | ||
YEL025C | unknown | Putative protein of unknown function | |||
YOR024W | • | unknown | Dubious open reading frame | ||
YOR118W | • | CR | unknown | Protein of unknown function | |
YPR038W | IRC16 | unknown | Dubious open reading frame, partially overlaps verified gene ERV2/YPR037C |