Fig. 7

Interfered Malat1 expression didn’t significantly change the hematopoietic differentiation but inhibited the proliferation of EML cells. a Inhibited Malat1 expression of EML cells by RNA interference, the decrease of Malat1 didn’t significantly change the expression of hematopoietic factor GATA2 and EKLF1, the means ± SD of three independent experiments are shown, P < 0.05 vs Mock control (control RNAi oligo). b EML cells were interfered with control RNAi oligo or Malat1 RNAi oligo, cell number was counted at 24 and 48 h, the graph showed the growth rate of EML cells plotted on a liner scale, the means ± SD of three independent experiments are shown, P < 0.05 vs Mock control (control RNAi oligo). c Schematic drawing shows a work model that ATRA induces hematopoietic differentiation and Malat1 down regulation. In this model, ATRA induces up regulation of GATA2, EKLF1 and tumor repressor p53, and therefore causes hematopoietic differentiation, on the other hand, p53 acts as a transcription factor inhibits Malat1 expression in EML cells, Malat1 played a role in maintaining proliferation potential of hematopoietic cells