Fig. 1From: Transcriptomic responses to prion disease in ratsInterspecies transmission of prion disease. Six prion agents were used for initial transmission to rats including transmissible mink encephalopathy (TME), skunk-adapted TME, hamster-adapted TME strain Hyper, Rocky Mountain Laboratories (RML) mouse-adapted scrapie, chronic wasting disease (CWD) from wild-type deer, and CWD from wt/96S deer. After 1 year of incubation, first passage rats were euthanized to determine the extent of PrP-res accumulation. PrP-res was observed solely in rats infected with RML scrapie prions. This agent was serially passaged until becoming rat-adapted, as indicated by the decrease in and stabilization of the incubation period. Third passage rat-adapted scrapie transmitted to mice and hamsters with 100Â % penetranceBack to article page