Table 3 The most enriched KEGG pathways of target genes for 23 differentially expressed miRNAs between the sera of C57BL/6NCrl mice during obesity and weight reduction by low-fat diet
Pathway | Count of genes | P-value | Pathway ID |
|---|---|---|---|
Metabolic pathways | 1024 | 2.11E06 | ko01100 |
MAPK signaling pathway | 514 | 1.82E05 | ko04010 |
Regulation of actin cytoskeleton | 471 | 3.09E05 | ko04810 |
Biosynthesis of secondary metabolites | 392 | 4.72E05 | ko05200 |
Focal adhesion | 342 | 6.21E10 | ko04510 |
Insulin signaling pathway | 318 | 5.13E05 | ko04910 |
Calcium signaling pathway | 295 | 5.34E05 | ko04020 |
Cytokine-cytokine receptor interaction | 228 | 2.16E04 | ko04060 |
Tight junction | 172 | 4.22E06 | ko04530 |
Phagosome | 144 | 2.14E05 | ko04145 |
Adipocytokine signaling pathway | 117 | 1.27E04 | ko04920 |