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Table 2 miRNAs significant for overall survival (Discovery cohort)

From: Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer

A. Case–control approach
miRNA ID Univariate Cox p-value Permuted p-value
hsa-miR-15a-5p 0.02 0.03
hsa-miR-660-5p 0.03 0.04
hsa-miR-574-3p 0.08 0.07
hsa-miR-27a-3p 0.06 0.07
B. Case-only approach
miRNA ID Univariate Cox p-value Permuted p-value
hsa-miR-210-3p 0.01 0.02
hsa-miR-15a-5p 0.02 0.03
hsa-miR-660-5p 0.03 0.04
hsa-miR-146b-5p 0.04 0.05
hsa-miR-374a-3p 0.04 0.05
hsa-miR-374a-5p 0.04 0.06
hsa-miR-27a-3p 0.06 0.07
hsa-miR-574-3p 0.08 0.07
hsa-miR-221-3p 0.07 0.08
hsa-miR-196a-5p 0.07 0.09
hsa-miR-425-5p 0.05 0.10
  1. A: 80 miRNAs were differentially expressed with Fold change > 2.0 and at a FDR cut off <0.05. All 80 miRNAs were subjected to Univariate Cox proportional hazards regression and permutation test (n = 10,000) for Overall Survival (OS). Four miRNAs were significant for OS and were used to construct a risk score. Univariate Cox p-value is the unpermuted p-value for Univariate Cox model. B: All the miRNAs (n = 147) retained after filtering (minimum 10 read counts in at least 90 % samples) in cases were considered for further analysis. 11 miRNAs were significant for OS with permuted p-value ≤ 0.1 and were considered for constructing a risk score. Univariate Cox p-value is the unpermuted p-value for Univariate Cox model