A. Case–control approach |
miRNA ID | Univariate Cox p-value | Permuted p-value |
hsa-miR-193b-3p | 0.09 | 0.09 |
hsa-miR-15a-5p | 0.08 | 0.10 |
B. Case-only approach |
miRNA ID | Univariate Cox p-value | Permuted p-value |
hsa-miR-210-3p | 0.01 | 0.02 |
hsa-miR-425-5p | 0.05 | 0.08 |
hsa-miR-193b-3p | 0.09 | 0.09 |
hsa-miR-15a-5p | 0.08 | 0.10 |
- A: 80 miRNAs were differentially expressed with Fold change > 2.0 and FDR cut off 0.05. All 80 miRNAs were subjected to Univariate Cox proportional hazards regression and permutation test (n = 10,000) for Recurrence Free Survival (RFS). Two miRNAs were significant for RFS with permutation p value ≤ 0.1 and were used for constructing risk score. Univariate Cox p-value is the unpermuted p-value for Univariate Cox model. B: All the miRNAs (n = 147) retained after filtering (minimum 10 read counts in at least 90 % samples) in cases were considered for further analysis. Four miRNAs were significant for RFS with permuted p-value ≤ 0.1 and were considered for constructing a risk score. Univariate Cox p-value is the unpermuted p-value for Univariate Cox model
