Skip to main content

Table 3 miRNAs significant for recurrence free survival (Discovery cohort)

From: Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer

A. Case–control approach
miRNA ID Univariate Cox p-value Permuted p-value
hsa-miR-193b-3p 0.09 0.09
hsa-miR-15a-5p 0.08 0.10
B. Case-only approach
miRNA ID Univariate Cox p-value Permuted p-value
hsa-miR-210-3p 0.01 0.02
hsa-miR-425-5p 0.05 0.08
hsa-miR-193b-3p 0.09 0.09
hsa-miR-15a-5p 0.08 0.10
  1. A: 80 miRNAs were differentially expressed with Fold change > 2.0 and FDR cut off 0.05. All 80 miRNAs were subjected to Univariate Cox proportional hazards regression and permutation test (n = 10,000) for Recurrence Free Survival (RFS). Two miRNAs were significant for RFS with permutation p value ≤ 0.1 and were used for constructing risk score. Univariate Cox p-value is the unpermuted p-value for Univariate Cox model. B: All the miRNAs (n = 147) retained after filtering (minimum 10 read counts in at least 90 % samples) in cases were considered for further analysis. Four miRNAs were significant for RFS with permuted p-value ≤ 0.1 and were considered for constructing a risk score. Univariate Cox p-value is the unpermuted p-value for Univariate Cox model