Fig. 5
Exons in the p53 pathway are significantly enriched for repeat instability. Box plots of the number of genes in the p53 pathway with unstable repeats and orphan repeats in their exons, for normal-normal genome pairs (left boxes, n = 595) and for tumor-matched normal genome pairs (right boxes, n = 35). Thick horizontal lines in each box mark the median, edges of boxes correspond to the 25th and 75th percentiles, and whiskers cover 99.3 % of the data’s range. Repeat instability is significantly different between tumor and normal genomes (WRS test, P = 0.03, P < 10−4, respectively, after Bonferroni correction)