Fig. 1
From: Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response
Gene expression changes triggered by gradual depletion of Pkh. a Number of genes found up-(empty bars) and down-regulated (filled bars) in SDP8 versus WT cells after 8 and 24 h of treatment with 100 μg/ml doxycycline. The percentage respect the total number of genes with valid expression value data are denoted in brackets. b Cluster analysis of the expression profiles caused by depletion of Pkh. Genes whose expression was found changed after treatment of SDP8 cells with doxycycline (either 8 or 24 h) when compared to wild-type cells under the same conditions were hierarchically clustered (complete linkage clustering, uncentered correlation) by means of the Gene Cluster (v. 2.11) software [72] and visualized with Java TreeView (v 3.0) [73]. Relevant functional categories of genes in each cluster are denoted