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Fig. 6 | BMC Genomics

Fig. 6

From: Helveticoside is a biologically active component of the seed extract of Descurainia sophia and induces reciprocal gene regulation in A549 human lung cancer cells

Fig. 6

Dose-dependent changes in pathway activity after helveticoside treatment in A549 cells. The pathway activities (FDR < 0.01), which were calculated by linear combinations of gene expression, were hierarchically clustered. For comparison, the statistically significant pathways (FDR < 0.01) after EEDS treatment are shown in parallel. For comparison, the pathway activity obtained for the 15 top-ranked chemicals selected from the Connectivity map analysis of EEDS is also displayed in parallel. The columns represent individual samples, and the rows represent pathways. The red and green colors reflect high and low activity levels, respectively, as indicated by the scale bar with arbitrary units. The pathways that were enriched based on the enrichment analysis (Table 2) and SPIA (Fig. 5) are also indicated in black in the right panel of the pathway activity bar. Signal-related pathways and metabolism-related pathways are colored red and blue, respectively, in the right panel.

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