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Fig. 7 | BMC Genomics

Fig. 7

From: Helveticoside is a biologically active component of the seed extract of Descurainia sophia and induces reciprocal gene regulation in A549 human lung cancer cells

Fig. 7

Interaction network of the genes induced by helveticoside in A549 cells. a The interaction network was constructed from 1,093 genes with the down-regulated pattern and 824 genes with the up-regulated pattern by implementing the Reactome FI application. In total, 11 modules (as indicated from 0 to 10) are shown in different colors. b The GO terms associated with this interaction network were analyzed by NOA, and top 10 enriched GO terms (p-value < 1.00E-10) were measured in the subgraph of GO-directed acyclic structure. c The network structure of the enriched GO terms in each module (FDR < 0.01) was obtained from the REVIGO program. The node size and color intensity are proportional to the hierarchical status and statistical significance of each node, respectively. The edge thickness between two nodes represents their closeness.

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BMC Genomics

ISSN: 1471-2164

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