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Table 3 Test statistics of previously identified mitochondria tRNAs with disease associations

From: Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes

  

Differential expression of tRNA MDS vs control

Linear regression association of tRNA with response

tRNA

Association

pAdj (DESeq2)

pAdj (edgeR)

pAdj (baySeq)

Effect

Std err

p value

MT-TF

MELAS, MT-TF-related, MERRF syndrome [88]

0.0103

0.0015

0.4869

−1.3378

3.5754

0.7129

MT-TV

Leigh syndrome, NARP, mitochondrial disorder [89]

0.0103

0.0020

0.6661

−0.1755

0.2952

0.5602

MT-TL1

myelodysplastic syndrome [39]

0.0299

0.0030

0.4143

0.7728

1.1559

0.5127

MT-TI

hypertrophic cardiomyopathy [90]

0.0431

0.0044

0.7070

−1.3977

2.8147

0.6258

MT-TQ

MELAS [91]

0.4745

0.0687

0.9095

−0.1673

0.2261

0.4693

MT-TM

mitochondria disorder, hypertension [92]

NA

0.0354

0.6065

−0.6015

0.2818

0.0476

MT-TW

neonatal onset mito disease [93]

0.0271

0.0040

0.4824

−18.3065

27.0968

0.5084

MT-TA

hearing loss [94]

0.0062

0.0015

0.2336

−33.3062

19.0142

0.0979

MT-TN

Ophthalmoplegia [95]

0.0134

0.0024

0.5159

−6.6839

3.0347

0.0417

MT-TC

hearing loss [96]

0.0006

0.0005

0.0011

−0.7931

1.1525

0.5006

MT-TY

mitochondrial cytopathy [97]

0.5648

0.0642

0.9019

0.0994

3.1135

0.9749

MT-TS1

hearing loss [98]

0.0017

0.0009

0.1043

−54.1283

17.2749

0.0061

MT-TD

mitochondrial myopathy [99]

NA

0.1135

0.8845

−14.0023

9.2086

0.1467

MT-TK

MELAS [100]

0.6851

0.1933

0.9098

−0.4508

0.5028

0.3825

MT-TG

hypertrophic cardiomyopathy [101]

0.0775

0.0067

0.7119

0.4488

4.0525

0.9131

MT-TR

mitochondria myopathy [102]

0.4745

0.1346

0.8194

−19.9639

10.4921

0.0742

MT-TH

MELAS [103]

0.1634

0.0251

0.8843

−0.4952

0.4202

0.2549

MT-TS2

mitochondrial myopathy [104]

0.0431

0.0043

0.8107

−0.0547

0.2504

0.8295

MT-TL2

ophthalmoplegia [105]

0.3483

0.0534

0.9062

−1.1874

1.2812

0.3670

MT-TE

myopathy [106]

0.0271

0.0045

0.5381

−0.3868

0.2411

0.1271

MT-TT

multiple sclerosis [107]

0.3483

0.0466

0.8629

−9.0631

11.8617

0.4553

MT-TP

mitochondrial catopathy [108]

0.0034

0.0007

0.4374

−4.2378

3.7122

0.2694