TY - JOUR AU - Yin, Shuang AU - Rusconi, Brigida AU - Sanjar, Fatemeh AU - Goswami, Kakolie AU - Xiaoli, Lingzi AU - Eppinger, Mark AU - Dudley, Edward G. PY - 2015 DA - 2015/09/29 TI - Escherichia coli O157:H7 strains harbor at least three distinct sequence types of Shiga toxin 2a-converting phages JO - BMC Genomics SP - 733 VL - 16 IS - 1 AB - Shiga toxin-producing Escherichia coli O157:H7 is a foodborne pathogen that causes severe human diseases including hemolytic uremic syndrome (HUS). The virulence factor that mediates HUS, Shiga toxin (Stx), is encoded within the genome of a lambdoid prophage. Although draft sequences are publicly available for a large number of E. coli O157:H7 strains, the high sequence similarity of stx-converting bacteriophages with other lambdoid prophages poses challenges to accurately assess the organization and plasticity among stx-converting phages due to assembly difficulties. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-015-1934-1 DO - 10.1186/s12864-015-1934-1 ID - Yin2015 ER -