Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio

Table 1 DDVP exposure results in injury to non-neural tissues

Exposure
Observation		Control	Low	Mid	High
• Myodegeneration	Mean Score	0	0	0.4	2.4^†
• Myodegeneration	Prevalence	0/4	0/5	2/5	5/5
• Testis degeneration	Mean Score	0.2	0.4	2.2^†	2.8^†
• Testis degeneration	Prevalence	1/4	2/5	5/5	5/5
• Pancreas zymogen granule depletion	Mean Score	0	0	2.2^†	2.4^†
• Pancreas zymogen granule depletion	Prevalence	0/4	0/5	4/5	5/5
Renal congestion	Mean Score	0	0.6	1.0	2.0^†
Renal congestion	Prevalence	0/4	2/5	3/5	4/5
Hepatic vacuolation	Mean Score	3.0	3.0	2.6	1.8
Hepatic vacuolation	Prevalence	4/4	5/5	5/5	5/5

Tissues were scored semiquantitatively for histomorphological features. Prevalence indicates the fraction of examined animals displaying a histopathological feature. Bullets indicate histological observations in exposed animals that are statistically different from control at p ≤ .05 using the Kruskal-Wallis test. Daggers indicate specific conditions different from control at p ≤ .05 (uncorrected) in post hoc testing with the Wilcoxon ranks test. See Additional file 2 for images of stained sections and more detail

ISSN: 1471-2164