|
Exposure
|
|---|
|
Observation
| |
Control
|
Low
|
Mid
|
High
|
|---|
|
• Myodegeneration
|
Mean Score
|
0
|
0
|
0.4
|
2.4†
|
|
Prevalence
|
0/4
|
0/5
|
2/5
|
5/5
|
|
• Testis degeneration
|
Mean Score
|
0.2
|
0.4
|
2.2†
|
2.8†
|
|
Prevalence
|
1/4
|
2/5
|
5/5
|
5/5
|
|
• Pancreas zymogen granule depletion
|
Mean Score
|
0
|
0
|
2.2†
|
2.4†
|
|
Prevalence
|
0/4
|
0/5
|
4/5
|
5/5
|
|
Renal congestion
|
Mean Score
|
0
|
0.6
|
1.0
|
2.0†
|
|
Prevalence
|
0/4
|
2/5
|
3/5
|
4/5
|
|
Hepatic vacuolation
|
Mean Score
|
3.0
|
3.0
|
2.6
|
1.8
|
|
Prevalence
|
4/4
|
5/5
|
5/5
|
5/5
|
- Tissues were scored semiquantitatively for histomorphological features. Prevalence indicates the fraction of examined animals displaying a histopathological feature. Bullets indicate histological observations in exposed animals that are statistically different from control at p ≤ .05 using the Kruskal-Wallis test. Daggers indicate specific conditions different from control at p ≤ .05 (uncorrected) in post hoc testing with the Wilcoxon ranks test. See Additional file 2 for images of stained sections and more detail
