Exposure | |||||
---|---|---|---|---|---|
Observation | Control | Low | Mid | High | |
• Myodegeneration | Mean Score | 0 | 0 | 0.4 | 2.4† |
Prevalence | 0/4 | 0/5 | 2/5 | 5/5 | |
• Testis degeneration | Mean Score | 0.2 | 0.4 | 2.2† | 2.8† |
Prevalence | 1/4 | 2/5 | 5/5 | 5/5 | |
• Pancreas zymogen granule depletion | Mean Score | 0 | 0 | 2.2† | 2.4† |
Prevalence | 0/4 | 0/5 | 4/5 | 5/5 | |
Renal congestion | Mean Score | 0 | 0.6 | 1.0 | 2.0† |
Prevalence | 0/4 | 2/5 | 3/5 | 4/5 | |
Hepatic vacuolation | Mean Score | 3.0 | 3.0 | 2.6 | 1.8 |
Prevalence | 4/4 | 5/5 | 5/5 | 5/5 |