1
|
Steroid biosynthesis
|
Squalene to 24,25-Dihydro-lanosterol
|
SQLE, ERG1, E5.4.99.7, LSS, ERG7, DHCR24
|
C. coralloides*, F. taffensis, M. capsulatus*, M. alcaliphilum, S. aurantiaca
|
7
|
Arginine and proline metabolism
|
N-Acetyl-glutamate - N-Acetyl-ornithine
|
argB, ARG56, argC, lysY, ARG56, E2.6.1.11, argD, argD, lysJ
|
E. coli*, S. enterica*, S. aureus*, L. monocytogenes, M. tuberculosis*
|
3
|
Biosynthesis of 12-, 14- and 16-membered macrolides
|
Propanoyl-CoA to Erythromycin A
|
E2.3.1.94, eryF, eryBV, eryCIII, eryCII, eryG, eryK
|
F. alni, S. erythraea,
|
2
|
Lysine biosynthesis
|
L-2-Amino adipate to Pyrrolysine
|
lysX, lysZ, lysY, lysJ, E2.4.1.173, pylB, pylC, pylD
|
T. thermophilus*, P. mucilaginosus, C. sp., D. hafniense, M. ruber
|
5
|
Glycine, serine and threonine metabolism
|
Choline - Glycine
|
codA, gbsB, BHMT, DMGDH, SARDH
|
B. amyloliquefaciens, B. subtilis, S. meliloti, R. sphaeroides, B. licheniformis
|
6
|
Arginine and proline metabolism
|
Creatine Pathway
|
GAMT, E2.7.3.2, E3.5.3.3, E3.5.1.59, hyuA, hyuB, E3.5.4.21
|
H. pylori*, P. putida, C. sp., A. mediterranei, G. sp.
|
11
|
Type I polyketide structures
|
Rifamycin B
|
rifA, rif14, rifB, rif20, rifC_D, rifE, rifF, asm9, rif19
|
A. mediterranei*, F. sp., A. mirum, M. aurantiaca, M. sp.
|
4
|
Biosynthesis of 12-, 14- and 16-membered macrolides
|
2-Methylbutanoyl to Avermectin
|
aveA, aveE, aveF, aveD, aveBI
|
S. avermitilis.
|
8
|
Streptomycin biosynthesis
|
scyllo-inosamine
|
stsE, strB1, E2.4.2.27, strK, K12570, aphD, strA
|
S. griseus
|
9
|
Type I polyketide structures
|
Erythromycin A
|
eryK, E2.3.1.94, eryF, E2.3.1.94, eryCIII, eryCII, E2.3.1.94, eryBV
|
F. alni, S. erythraea.
|
10
|
Type I polyketide structures
|
Avermectin A1a
|
aveA, aveBI, aveE, aveF, aveD
|
S. avermitilis,
|
12
|
Type I polyketide structures
|
Myalamid S
|
mxaB, mxaE_D, mxaF
|
G. violaceus, H. ochraceum, H. aurantiacus, M. xanthus, N. punctiforme
|
13
|
Biosynthesis of type II polyketide backbone
|
7,9,12-Octaketides
|
actI1, actI2, actI3, actIII, actVII
|
A. mediterranei*, F. sp., A. missouriensis, C. acidiphila*, C. epipsammum
|
14
|
Biosynthesis of type II polyketide products
|
7,9,12-Octaketides - Actinorhodin
|
actVI1, RED1, actVI3, actVI2, actIV, actVI4, actVA6, actVIA, actVA5, actVB
|
A. mediterranei*, F. sp., M. abscessus, S. cattleya, A. ferrooxidans
|
15
|
Serotonergic synapse
|
Signal transduction
|
PLA2G4, CPLA2, ALOX5, PTGS2, COX2, PTGS2, COX2
|
R. sphaeroides*, C. coralloides, G. obscurus, M. nodulans, M. sp.
|
16
|
Insulin signaling pathway
|
Glycogenesis/ antilipolysos
|
GYS, CALM, PHKA_B, PRKAR
|
S. sp., C. sp., A. sp., B. coagulans, C. sp.
|
17
|
Chemical carcinogenesis
|
Azo dyes/Liver cancer/Bladder cancer
|
PTGS2, COX2, CYP1A1
|
R. sphaeroides*, G. obscurus, M. mediterranea, M. nodulans, M. sp.
|