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Fig. 2 | BMC Genomics

Fig. 2

From: Complexity of a small non-protein coding sequence in chromosomal region 22q11.2: presence of specialized DNA secondary structures and RNA exon/intron motifs

Fig. 2

Alignment of human and chimpanzee sequences that shows formation or loss of TATAATATA motif. Three separate alignment programs gave similar alignments in the small genomic segments shown above. The nature of mutations, whether a base change, sequence addition or oligo-insertion in the human sequence occurred is shown. Color code: blue, TATAATATA motif formed, red, mutations destroy motif. a bp substitution creates TATAATATA motif in human sequence (however, we can not rule out a point mutation in the chimpanzee sequence destroyed a TATAATATA motif). b Oligo-bp insertions in human sequence eliminates two overlapping TATAATATA motifs. c Oligo-bp insertion in human sequence adds motif, another motif is conserved between two species, and two bp substitutions create a motif in human. Alignments are by Emboss Needle (www.ebi.ac.uk/Tools/psa/emboss_needle/)

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