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Fig. 4 | BMC Genomics

Fig. 4

From: Integrated ordination of miRNA and mRNA expression profiles

Fig. 4

MDS mapping of mRNAs differentially expressed in ALF livers. MDS was applied to a 640 × 640 square matrix including the Kendall correlations among 109 miRNAs and 531 mRNAs differentially expressed in ALF livers. This figure shows only a subset of 87 mRNAs functionally related to CYP450, transcription factors, complement, HLA class II, monocytes/macrophages, T cells, T-NK cells and B cells. These nine functional classes are delimited by dispersion ellipses with a confidence of 1.6 standard deviations. A 360° rotation of 3D ellipses is shown in the Additional file 2: Movie 1. The nine ellipses are also shown in the next Figs. 5, 6, 7 and 8 for reference. The numbers in parentheses, on the right of gene symbols, are the fold changes of original data, not corrected for necrosis. A prominent segregation of leukocyte-related mRNAs from hepatocyte-related mRNAs is apparent

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