Fig. 3

The distribution of predicted protein functions (a) in the core genome, (b) in the accessory genome of C. diphtheriae. The distribution of the functional protein categories based on the similarities in the Clusters of Orthologous Genes (COG) database within predicted (c). Transmembrane proteins (outer circle), (d) secreted proteins (outer circle) and (e) cytoplasmic proteins. The proportion of different types of membrane-associated and secreted proteins is shown in the inner circles within panel c and d, respectively. (COG codes - A: RNA processing and modification; B: Chromatin structure and dynamics; C: Energy production and conversion; D: Cell cycle control, cell division, chromosome partitioning; E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism; G: Carbohydrate transport and metabolism; H: Coenzyme transport and metabolism; I: Lipid transport and metabolism; J: Translation, ribosomal structure and biogenesis; K: Transcription; L: Replication, recombination and repair; M: Cell wall/membrane/envelope biogenesis; N: Cell motility; O: Post-translational modification, protein turnover, and chaperones; P: Inorganic ion transport and metabolism; Q: Secondary metabolites biosynthesis, transport, and catabolism; T: Signal transduction mechanisms; U: Intracellular trafficking, secretion, and vesicular transport; V: Defence mechanisms; W: Extracellular structures; Y: Nuclear structure; Z: Cytoskeleton; Not assigned: General function prediction and unknown function)