Fig. 1

Identification of cell type-specific metabolic pathways in primary human cells. a 156 metabolic models based on an equal number of microarrays and corresponding to 63 primary human cell types were built using the FASTCORMICS workflow and microarray collection from Primary Cell Atlas (GSE49910). The level of similarity between the different model pairs was determined via the Jaccard index. The Jaccard index matrix was then clustered in function of the similarity level. b For each pathway, the level of activity, given as percentage of reactions of the consistent version of Recon 2 (5317 reactions) that are present in each context-specific model was computed. The distribution of the activity levels of each pathway across the 156 models are shown as box plots and sorted according to the median value across the pathways. Pathways that contain less than 4 reactions were not included. Mean percentage of active reactions across macrophage and monocyte samples are depicted by black asterisk (*) and green cross (x), respectively