Skip to main content
Fig. 5 | BMC Genomics

Fig. 5

From: Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network

Fig. 5

High-regulatory load genes show macrophage specific expression and are the highest expressed genes in their respective pathways. The normalized expression values of the 745 arrays of Primary Cells Atlas were downloaded from the Gene Expression Omnibus repository (GSE49910). The 745 arrays are subdivided in 188 separate cellular contexts. For each reactions-related gene of a pathway, the normalized expression value was retrieved and for each gene, the 188 conditions were ranked from the highest expressed to the lowest expression level with the ImpAvRank function from [74]. For each pathway, the genes are plotted in function of the rank of the monocyte-derived macrophages among the 188 conditions. Each rank position is represented as a box along the y-axis. High-regulatory load genes are mapped along this axis in function of their rank and depicted in orange, whereas the remaining genes in the pathway are depicted in dark gray

Back to article page