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Fig. 3 | BMC Genomics

Fig. 3

From: Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis

Fig. 3

A potential route for pyrimidine and chitin precursor acquisition by T. hominis. De novo routes for pyrimidine biosynthesis are not present in Microsporidia, but scavenger pathways allow conversion between different pyrimidines [11]. The import of only one pyrimidine from the host cell would, in principle, enable the biosynthesis of other pyrimidines via scavenger pathways, because interconversions between bases are possible. NupG-like transport proteins have been hypothesised to transport nucleosides and thus act as a source of pyrimidine precursors [16], but the specificity and subcellular localisation of these genes are currently unknown. A putative UDP-N-acetyl glucosamine transporter provides another potential source of pyrimidines in T. hominis and V. culicis: the imported metabolite can feed into chitin synthase and glycosylation pathways, both of which may liberate free pyrimidine

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