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Table 3 Top 15 KEGG Pathways Enriched in Genes Affected by CNVs in Qatarisa

From: Copy number variations in the genome of the Qatari population

Kegg pathway Number of genes Fold-enrichment p value
Notch signaling pathway 16 2.7 4.4 × 10−4
Starch and sucrose metabolism 14 2.6 1.5 × 10−3
Focal adhesion 39 1.5 6.4 × 10−3
mTOR signaling pathway 14 2.1 1.1 × 10−2
Purine metabolism 30 1.5 1.6 × 10−2
Antigen processing and presentation 19 1.8 1.4 × 10−2
Axon guidance 25 1.5 3.2 × 10−2
Type II diabetes mellitus 12 2 3.0 × 10−2
Drug metabolism 14 1.8 4.4 × 10−2
Extracellular matrix - receptor interaction 17 1.6 6.0 × 10−2
Type I diabetes mellitus 10 1.9 7.6 × 10−2
Non-small cell lung cancer 12 1.8 7.2 × 10−2
Insulin signaling pathway 24 1.4 8.2 × 10−2
Metabolism of xenobiotics by cytochrome P450 13 1.7 7.0 × 10−2
Maturity onset diabetes of the young 7 2.2 8.7 × 10−2
  1. aAll genes affected by CNVs in Qataris were analyzed by DAVID bioinformatics resources for KEGG pathways. Number of genes in each enriched KEGG Pathway, along with the fold-enrichment within each pathway and a p value for the significance of enrichment