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Table 6 Top 10 Cytobands in Which Qatari Genetic Subpopulations’ CNVRs were Observed at a Significantly Higher Frequency than in 1000 Genomes Phase I CNV Dataa

From: Copy number variations in the genome of the Qatari population

Qatari genetic subpopulation Cytoband 1000Genomes phase I count Q1, Q2 or Q3 count p value Diseases associated with cytoband
Q1 1q21.1 10 55 1.60 × 10−16 Schizophrenia; congenital heart disease
  9q21.11 5 42 1.06 × 10−14 -
  5q13.2 6 35 3.43 × 10−11 Neurologic disorders; alcohol dependence
  9p11.2 17 49 8.97 × 10−11 -
  16p11.2 23 50 7.10 × 10−9 Autism; schizophrenia; obesity
  10q11.22 7 29 2.45 × 10−8 -
  9p12 14 38 2.66 × 10−8 -
  8p11.1 2 20 7.14 × 10−8 -
  9p13.1 8 29 7.55 × 10−8 -
  7q11.1 3 20 3.66 × 10−7 -
Q2 1q21.1 10 59 9.67 × 10−22 Schizophrenia; congenital heart disease
  5q13.2 6 36 8.21 × 10−14 Neurologic disorders; alcohol dependence
  9q21.11 5 33 4.22 × 10−13 -
  16p11.2 23 51 8.07 × 10−12 Autism; schizophrenia; obesity
  9p11.2 17 44 1.17 × 10−11 -
  7q11.1 3 25 8.91 × 10−11 -
  8p11.1 2 20 3.77 × 10−9 -
  7q11.21 35 53 5.43 × 10−9 -
  10q11.22 7 26 8.97 × 10−9 -
  9p12 14 30 1.76 × 10−7 -
Q3 1q21.1 10 60 2.04 × 10−20 Schizophrenia; congenital heart disease
  9q21.11 5 37 7.23 × 10−14 -
  9p11.2 17 48 6.27 × 10−12 -
  16p11.2 23 54 1.26 × 10−11 Autism; schizophrenia; obesity
  5q13.2 6 33 1.83 × 10−11 Neurologic disorders; alcohol dependence
  10q11.22 7 29 3.10 × 10−9 -
  7q11.1 3 21 3.00 × 10−8 -
  22q11.1 7 25 1.20 × 10−7 -
  8p11.1 2 18 1.24 × 10−7 -
  1p36.33 12 30 2.87 × 10−7 Disorders of sexual development; obesity
  1. aAll CNVRs detected in Q1, Q2 and Q3 Qataris as well as all CNVRs in the Database of Genomic Variantsfrom the 1000 Genomes Project Phase I [25] data were annotated for which chromosome and cytoband they affected. Fisher’s exact test was used to evaluate enrichment or depletion of CNVRs from a specific cytoband, corrected p value for significance (<6.7 × 10−6)