Table 4 Multivariate Cox regression analysis including the level of methylation in the cancer-specific cluster “3up” in addition to significant clinical variables for breast cancer
From: Changes in correlation between promoter methylation and gene expression in cancer
Clinical variable (Reference) | HR (95 % CI) | p-value |
|---|---|---|
Cluster 3up (Low vs intermediate) | 3.44 (1.44–8.23) | 0.007 |
Cluster 3up (Low vs high) | 1.92 (0.50–7.34) | 0.34 |
(ER,HER2) (-/- vs +/-) | 0.37 (0.15–0.88) | 0.026 |
(ER,HER2) (-/- vs -/+) | 1×10−8 (0–Inf) | 1 |
(ER,HER2) (-/- vs +/+) | 0.53 (0.09–2.94) | 0.46 |
Lymph Node (Negative) | 4.51 (1.63–12.44) | 0.004 |