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Table 4 Multivariate Cox regression analysis including the level of methylation in the cancer-specific cluster “3up” in addition to significant clinical variables for breast cancer

From: Changes in correlation between promoter methylation and gene expression in cancer

Clinical variable (Reference) HR (95 % CI) p-value
Cluster 3up (Low vs intermediate) 3.44 (1.44–8.23) 0.007
Cluster 3up (Low vs high) 1.92 (0.50–7.34) 0.34
(ER,HER2) (-/- vs +/-) 0.37 (0.15–0.88) 0.026
(ER,HER2) (-/- vs -/+) 1×10−8 (0–Inf) 1
(ER,HER2) (-/- vs +/+) 0.53 (0.09–2.94) 0.46
Lymph Node (Negative) 4.51 (1.63–12.44) 0.004