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Table 3 Highly over-expressed genes identified in the white isthmus during deposition of the eggshell membranesa

From: Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics

Gene symbol Entrez gene name WI/Ut (fold change) WI/Ma (fold change) Secretion Confirmed by proteomics
SignalPb SecretomePc ESd membranes ESd matrix
COL10A1 Collagen α-1(X) chain-like 111.43; 50.21 155.42; 94.35 Yes - [7, 17, 18] [6, 35, 38]
R3HCC1 R3H domain and coiled-coil containing 1 79.34 136.24 - - - -
CREMP PREDICTED: similar to spore coat protein SP75, partial 70.03 58.08 - Yes [7, 17, 18] -
AP1G1 Adaptor-related protein complex 1, gamma 1 subunit 45.89 15.56 - - - -
FBN1 Fibrillin 1 45.89 2.53 - - - -
FCGBP IgGFc-binding protein-like 22.63; 7.62 34.06; 8.82 Yes - - -
MXI1 MAX interactor 1 14.12 9.85 - - - -
LIMCH1 LIM and calponin homology domains-containing protein 1 11.63 15.45 - - - -
FAM164C Family with sequence similarity 164, member C 3.71 2.79 - Yes - -
TDRD9 putative ATP-dependent RNA helicase 3.36 2.68 - Yes - -
HPX Hemopexin 2.95 1.57 - Yes [7, 17, 18] [6, 35, 38]
TMEM63C Transmembrane protein 63C 2.58 2.16 - - - -
SORD Sorbitol dehydrogenase 2.48 2.25 - Yes - -
PHGDH D-3-phosphoglycerate dehydrogenase 1.79 2.39 - Yes - -
TXN Thioredoxin 1.66 2.06 - - [7, 17] [35]
  1. aHigh over-expression defined as ≥ 2-fold (Log2 Ratio ≥ 1.0) relative to either the magnum or the uterus
  2. bPredicted by SignalP 4.1 software
  3. cPredicted by SecretomeP 2.0 software
  4. dES Eggshell