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Table 4 Over-expression of collagens and collagen-modifying genes in the chicken oviduct

From: Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics

Gene Collagen type Chain WI/Ut (fold change)a WI/Ma (fold change)a Confirmed by Proteomics
ESb membranes ESb matrix
COL1A1 I α-1 - 1.23 - [34]
COL1A2   α-2 - 1.18 [17] [34, 38]
COL2A1 II α-1 - - - [6, 35, 38]
COL3A1 III α-1 - 1.43; 1.16 - [34]
COL4A1 IV α-1 - - - -
COL4A2   α-2 - - - -
COL4A3   α-3 - - [17] -
COL5A1 V α-1 - - - -
COL5A2   α-2 - - [17] [35]
COL6A1 VI α-1 - - - [38]
COL6A2   α-2 - - [18] [6, 35, 38]
COL7A1 VII α-1 - - - [38]
COL8A1 VIII α-1 - - - -
COL10A1 X α-1 111.43; 50.21 155.42; 94.35 [7, 17, 31] [6, 35, 38]
COL17A1 XVII α-1 - - - [6, 38]
COL18A1 XVIII α-1 - - - [35]
COL20A1 XX α-1 - - - -
COL22A1 XXII α-1 - - - -
COL24A1 XXIV α-1 - - [19] -
  Collagen-modifying enzymes      
LOX Lysyl Oxidase - - - - -
LOXL1 Lysyl oxidase-like 1 - ** ** - -
LOXL2 Lysyl oxidase-like 2 - 18.64 - [7, 17] [6, 33, 38]
LOXL3 Lysyl oxidase-like 3 - - 1.27 [17, 18, 31] [38]
LOXL4 Lysyl oxidase-like 4 - - - [19] -
P4HA2 Prolyl 4-hydroxylase α-2 1.21 1.64 - -
P4HB Prolyl 4-hydroxylase β - 1.27 - [6]
PPIC Peptidyl-prolyl cis-trans isomerase C - 1.28 1.51 [17] [6, 35, 38]
  1. a. **Expressed at very high (saturating) levels in all three tissues
  2. b. ES - Eggshell