Table 3 Mutational events and their consequences for TCS gene sets

Chromosomal Rearrangements

~1-2 %

~3 %

Gene gain/loss.

Large (≥1 gene) indels

~10 %

~20

Gene gain/loss, with occasional changes in gene organisation (in ~10 % of cases).

 - Duplications

<<1 %

~3 %

Gene gain.

 - Horizontal transfer

~2 %

~4 %

Gene gain.

Small (<1 gene) indels

~1-2 %

~3 %

Domain gain/loss, changes in family.

 - Frameshifts

<1 %

~1 %

Change in family (often through changes in RR output domains), pseudogene formation.