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Table 3 Mutational events and their consequences for TCS gene sets

From: Genome-wide analysis of myxobacterial two-component systems: genome relatedness and evolutionary changes

Apparent mutational event Within-genus frequency (%) Within-family frequency (%) Typical consequences
Chromosomal Rearrangements ~1-2 % ~3 % Gene gain/loss.
Large (≥1 gene) indels ~10 % ~20 Gene gain/loss, with occasional changes in gene organisation (in ~10 % of cases).
 - Duplications <<1 % ~3 % Gene gain.
 - Horizontal transfer ~2 % ~4 % Gene gain.
Small (<1 gene) indels ~1-2 % ~3 % Domain gain/loss, changes in family.
 - Frameshifts <1 % ~1 % Change in family (often through changes in RR output domains), pseudogene formation.
  1. Percentages of orthologous clusters which show evidence of evolutionary changes when comparing genomes from the same genus (within-genus) and the same family (within-family). Percentages obtained from pairwise comparisons between Cystobacterineae members