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Fig. 2 | BMC Genomics

Fig. 2

From: Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist

Fig. 2

Differential effect of F. tularensis SchuS4 infection on E. coli LPS-responsive gene expression. a Expression profiles of LPS-responsive sequences that are not suppressed (upper panel), partially suppressed (middle panel) or suppressed (lower panel) by prior FT Schu4 infection. Each column represents gene expression data from an individual experiment comparing RNA from lung tissue from an infected animal to pooled RNA isolated from mock animals (n = 6). Sequences shown in red represent increased expression, sequences shown in green represent decreased expression and sequences in black indicate no change in expression in treated relative to control animals. Bar graphs represent expression levels (measured by microarray) of individual LPS-responsive genes that were not suppressed (b) partially suppressed (c) or suppressed (d) by prior FT SchuS4 infection. Data represents mean fold-change and standard deviation of two or three individual animals relative to control animals. Only sequences that were 3-fold induced (p value < 0.01) in all three LPS-exposed control animals (n = 978) were used for this analysis

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