Table 1 oPOSSUM 3.0 results for LPS-induced genes suppressed, not suppressed or partially suppressed by F. tularenesis

TF

Family

Z-score

Fischer score

q-value

Z-score

Fisher score

q-value

Z-score

Fisher score

q-value

Z-score

Fisher score

q-value

AP1

Leucine Zipper

5.492

49.37

0.0004501

Ar

Hormone-nuclear Receptor

9.599

8.988

0

7.618

7.526

5.36E-10

ARID3A

Arid

18.069

53.054

0

20.009

38.878

0

6.948

15.813

2.65E-07

CEBPA

Leucine Zipper

17.508

56.795

0

7.313

24.871

5.02E-09

7.727

19.6

1.11E-09

Egr1

BetaBetaAlph-zinc finger

9.242

35.76

0

10.597

15.075

0

FOXA1

Forkhead

9.272

46.98

0

9.751

29.455

0

Foxa2

Forkhead

7.135

47.333

1.38E-08

12.479

41.802

0

FOXD1

Forkhead

13.729

53.842

0

14.463

39.964

0

Foxd3

Forkhead

17.779

49.257

0

15.734

40.563

0

FOXF2

Forkhead

6.49

20.958

1.10E-06

7.19

21.679

1.20E-08

FOXI2

Forkhead

14.135

36.86

0

16.058

36.651

0

FOXO3

Forkhead

14.321

50.651

0

12.83

37.983

0

5.324

14.497

0.003402

Foxq1

Forkhead

10.523

44.105

0

11.804

42.968

0

Gatal

GATA

9.843

45.572

0

6.597

31.379

7.22E-07

0.013187

Gfi

BetaBetaAlpha-zinc finger

12.107

48.885

0

7.9

15.946

3.61E-10

HLF

Leucine Zipper

11.858

24.551

0

HOXAS

Homeo

19.619

55.444

0

20.668

35.237

0

5.306

16.325

0.003501

IRFI

IRF

16.593

37.42

0

11.588

30.497

0

6.563

11.061

2.93E-06

IRF2

IRF

10.478

10.828

0

Lhx3

Homeo

10.204

21.206

0

15.823

27.512

0

MEF2A

MADS

11.261

28.869

0

5.667

22.212

0.000234

5.164

9.596

0.007108

MIZF

BetaBetaAlpha-zinc finger

5.96

15.897

3.14E-05

8.243

20.427

4.82E-12

NFATC2

Rel

7.841

54.491

6.71E-11

7.61

8.397

1.70E-09

NFE2L2

Leucine Zipper

5.901

27.696

4.39E-05

NFIL3

Leucine Zipper

14.295

38.826

0

9.437

35.141

0

NF-kappaB

Rel

13.665

56.778

0

39.032

14.744

0

5.492

16.553

0.001656

NFKB1

Rel

5.708

14.056

0.0001325

Nkx2-5

Homeo

22.118

58.941

0

26.88

44.266

0

NKX3-1

Homeo

15.244

41.36

0

17.48

37.027

0

Nobox

Homeo

9.798

46.489

0

12.618

43.858

0

Pax6

Homeo

6.502

10.168

1.04E-06

10.422

16.405

0

Pdx1

Homeo

13.632

51.723

0

19.67

41.917

0

PLAG1

BetaBetaAlpha-zinc finger

7.702

14.764

1.95E-10

Pou5fl

Homeo

6.767

12.53

1.77E-07

Pnx2

Homeo

14.121

49.554

0

18.221

38.381

0

REL

Rel

11.771

55.54

0

30.632

10.072

0

5.323

11.424

0.003402

RELA

Rel

13.26

45.068

0

42.057

16.996

0

5.945

9.196

0.000138

Sox5

High Mobility Group

15.026

49.598

0

18.695

46.646

0

5.001

15.29

0.013577

SOX9

High Mobility Group

8.54

45.725

0

12.388

30.748

0

SPIB

Ets

5.794

74.595

8.15E-05

9.177

7.168

0

SRF

MADS

8.106

8.71

6.92E-12

STAT1

Stat

6.86

30.655

9.53E-08

20.574

7.325

0

TBP

TATA-binding

14.562

52.455

0

11.841

43.297

0

7.908

14.859

3.61E-10