Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals

Table 1 Detoxification-related transcripts differentially expressed after IVM ingestion

Gene ID	Description	Function	2IVM:2BF FC	6IVM:6BF FC
AGAP011824	Thioredoxin peroxidase	Reduction of H₂O₂	21.77	27.61
AGAP004382	Glutathione-S-transferase, delta 3	Conjugation of GSH to xenobiotics	3.62	-
AGAP006380	ABC transporter, subfamily A, member 3	Efflux pump	2.69	2.36
AGAP012296	Cytochrome P450 9 J5	Oxidation of toxic compounds	2.61	-
AGAP009463	ABC transporter, subfamily G, member 1	Efflux pump	-	−2.94
AGAP008219	Cytochrome P450 6Z1	Oxidation of toxic compounds	-	2.92
AGAP009738	Glutaredoxin	Redox homeostasis	-	2.39

Detoxification and oxidative-stress response related transcripts significantly differentially expressed upon IVM ingestion in both age groups

ISSN: 1471-2164