Table 3 Summary of the locations and functions of candidate genes that could play an important role in the immune response to P. salmonis infection and that have been identified in regions surrounding the most significant markers
| Gene | Position in contig | Function/comments | Reference |
|---|---|---|---|
| Alpha-1,3-fucosyltransferase 10 |
jcf1000860129_0-0_ssa01: 2897333..2936162 (− strand) | Neutrophil and T cells recruitment, lymphocyte trafficking. | [39–41] |
| Interleukin 31 receptor A | jcf1000860129_0-0_ssa01:3283056..3291004 (+ strand) | Involved in IL-31 signaling via activation of STAT-3 and STAT-5. Potentially involved in the development and function of monocytes and macrophages. | [50, 51] |
| Interleukin 6 signal transducer | jcf1000860129_0-0_ssa01:3294763..3315063 (− strand) | Signal transducer shared by many cytokines, including interleukin 6. This protein functions as a part of the cytokine receptor complex. | [52] |
| Granulocyte colony-stimulating factor receptor | jcf1000860129_0-0_ssa01:3294763..3315063 (− strand) | Regulation of myelopoiesis, promotion of the survival, proliferation and differentiation of Granulocyte-Macrophages Progenitors. Chemoattractive to immature and mature neutrophils; enhances neutrophil anti-microbial functions and neutrophil survival. Can also promote monocytes to differentiate into inflammatory dendritic cells. | [53, 54] |
| Mitogen-activated protein kinase kinase kinase (MAPKKK) | jcf1000860129_0-0_ssa01:3441205..3459556 (+ strand) | Participates in the activation of MAPK, which is crucial for transcriptional and nontranscriptional responses of the immune system. Upregulated in Atlantic salmon infected with P. salmonis. | [42, 55] |
| Metalloprotease ATP23 |
jcf1001033219_0-0_ssa17: 1317970..1353399 (− strand) | Matrix metalloproteinase are upregulated in Atlantic salmon infected with P. salmonis | [42] |
| TNF receptor-associated factor 2 | ccf1000000073_0-0_ssa01:2138109..2155775 (− strand) | Required for normal antibody isotype switching from IgM to IgG. Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. | [56, 57] |