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Table 3 Gene Ontology analysis of genes up-regulated in response to DHA in P. falciparum K1 trophozoites from RNA-seq analysis

From: Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Term Count List Total Pop Hits Pop Total PValue FDR
GO:0009536 ~ plastid 122 233 405 963 2.5E–04 0.31
GO:0006468 ~ protein amino acid phosphorylation 25 282 51 1139 3.1E–04 0.45
GO:0020011 ~ apicoplast 121 233 403 963 3.3E–04 0.41
GO:0006793 ~ phosphorus metabolic process 35 282 85 1139 8.4E–04 1.20
GO:0006796 ~ phosphate metabolic process 35 282 85 1139 8.4E–04 1.20
GO:0004674 ~ protein serine/threonine kinase activity 22 353 44 1385 9.6E–04 1.31
GO:0016310 ~ phosphorylation 30 282 70 1139 1.1E–03 1.52
  1. Enrichment of GO terms in 1211 significantly up-regulated genes (gene list) was calculated relative to the total of 4636 genes detected as expressed in this stage (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering