Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Table 3 Gene Ontology analysis of genes up-regulated in response to DHA in P. falciparum K1 trophozoites from RNA-seq analysis

Term	Count	List Total	Pop Hits	Pop Total	PValue	FDR
GO:0009536 ~ plastid	122	233	405	963	2.5E–04	0.31
GO:0006468 ~ protein amino acid phosphorylation	25	282	51	1139	3.1E–04	0.45
GO:0020011 ~ apicoplast	121	233	403	963	3.3E–04	0.41
GO:0006793 ~ phosphorus metabolic process	35	282	85	1139	8.4E–04	1.20
GO:0006796 ~ phosphate metabolic process	35	282	85	1139	8.4E–04	1.20
GO:0004674 ~ protein serine/threonine kinase activity	22	353	44	1385	9.6E–04	1.31
GO:0016310 ~ phosphorylation	30	282	70	1139	1.1E–03	1.52

Enrichment of GO terms in 1211 significantly up-regulated genes (gene list) was calculated relative to the total of 4636 genes detected as expressed in this stage (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering

ISSN: 1471-2164