Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Table 4 Gene Ontology analysis of genes differentially expressed in response to DHA in P. berghei ANKA from RNA-seq analysis

Term	Count	List Total	Pop Hits	Pop Total	PValue	FDR
GO:0043228 ~ non-membrane-bounded organelle	15	21	178	856	2.2E–06	0.002
GO:0043232 ~ intracellular non-membrane-bounded organelle	15	21	178	856	2.2E–06	0.002
GO:0005198 ~ structural molecule activity	11	30	113	1247	1.2E–04	0.121
GO:0003735 ~ structural constituent of ribosome	10	30	95	1247	1.7E–04	0.174
GO:0044445 ~ cytosolic part	8	21	59	856	2.0E–04	0.177
GO:0005829 ~ cytosol	9	21	82	856	2.5E–04	0.220
GO:0015935 ~ small ribosomal subunit	6	21	34	856	7.4E–04	0.658
GO:0022627 ~ cytosolic small ribosomal subunit	5	21	22	856	1.2E–03	1.078
GO:0006412 ~ translation	12	29	168	1023	2.8E–03	3.199
GO:0006096 ~ glycolysis	4	29	13	1023	4.4E–03	4.910

GO analysis was performed using corresponding P. falciparum orthologous genes. Enrichment of GO terms in 68 differentially expressed genes with P. falciparum orthologues (gene list) was calculated relative to the total of 4084 genes detected as expressed in the P. berghei ANKA samples with P. falciparum orthologues (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering

ISSN: 1471-2164