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Table 4 Gene Ontology analysis of genes differentially expressed in response to DHA in P. berghei ANKA from RNA-seq analysis

From: Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Term Count List Total Pop Hits Pop Total PValue FDR
GO:0043228 ~ non-membrane-bounded organelle 15 21 178 856 2.2E–06 0.002
GO:0043232 ~ intracellular non-membrane-bounded organelle 15 21 178 856 2.2E–06 0.002
GO:0005198 ~ structural molecule activity 11 30 113 1247 1.2E–04 0.121
GO:0003735 ~ structural constituent of ribosome 10 30 95 1247 1.7E–04 0.174
GO:0044445 ~ cytosolic part 8 21 59 856 2.0E–04 0.177
GO:0005829 ~ cytosol 9 21 82 856 2.5E–04 0.220
GO:0015935 ~ small ribosomal subunit 6 21 34 856 7.4E–04 0.658
GO:0022627 ~ cytosolic small ribosomal subunit 5 21 22 856 1.2E–03 1.078
GO:0006412 ~ translation 12 29 168 1023 2.8E–03 3.199
GO:0006096 ~ glycolysis 4 29 13 1023 4.4E–03 4.910
  1. GO analysis was performed using corresponding P. falciparum orthologous genes. Enrichment of GO terms in 68 differentially expressed genes with P. falciparum orthologues (gene list) was calculated relative to the total of 4084 genes detected as expressed in the P. berghei ANKA samples with P. falciparum orthologues (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering