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Fig. 3 | BMC Genomics

Fig. 3

From: VariantMetaCaller: automated fusion of variant calling pipelines for quantitative, precision-based filtering

Fig. 3

Precision-sensitivity curves at selected coverage depths for simulated data. Precision and sensitivity (recall) was calculated for each variant of the hard filtered call sets of four individual variant callers and for the results of VariantMetaCaller. Precision was plotted against sensitivity for SNPs (a) and for indels (b) at two selected coverage depths (8× and 200× representing low and high coverage, respectively). The rows differentiate between alignment algorithms and the columns represent different coverage depths. Variant calling was performed on five sample groups each containing ten samples. Bands around lines represent 95 % confidence intervals based on the results of the different sample groups. FB = FreeBayes, HC = HaplotypeCaller, ST = SAMtools, UG = UnifiedGenotyper, VMC = VariantMetaCaller

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BMC Genomics

ISSN: 1471-2164

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